Physical activity in relation to cardiovascular disease and total mortality among men with type 2 diabetes

Circulation. 2003 May 20;107(19):2435-9. doi: 10.1161/01.CIR.0000066906.11109.1F. Epub 2003 Apr 28.


Background: The present study was conducted to examine the relationship of physical activity with risk of cardiovascular disease (CVD) and mortality among men with type 2 diabetes. CVD risk and mortality are increased in type 2 diabetes. Few epidemiological studies have investigated the effect of physical activity on these outcomes among type 2 diabetics.

Methods and results: Of the 3058 men who reported a diagnosis of diabetes at age 30 years or older in the Health Professionals' Follow-up Study (HPFS), we excluded 255 who reported a physical impairment. In the remaining 2803 men, physical activity was assessed every 2 years; 266 new cases of CVD and 355 deaths of all causes were identified during 14 years of follow-up. Relative risks of CVD and death were estimated from Cox proportional hazards analysis with adjustment for potential confounders. The multivariate relative risks of CVD incidence corresponding to quintiles of total physical activity were 1.0, 0.87, 0.64, 0.72, and 0.67 (Ptrend=0.07). The corresponding multivariate relative risks for total mortality were 1.0, 0.80, 0.57, 0.58, and 0.58 (Ptrend=0.005). Walking was associated with reduced risk of total mortality. Relative risks across quintiles of walking were 1.0, 0.97, 0.87, 0.97, and 0.57 (Ptrend=0.002). Walking pace was inversely associated with CVD, fatal CVD, and total mortality independently of walking hours.

Conclusions: Physical activity was associated with reduced risk of CVD, cardiovascular death, and total mortality in men with type 2 diabetes. Walking and walking pace were associated with reduced total mortality.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Body Mass Index
  • Cardiovascular Diseases / mortality*
  • Cohort Studies
  • Comorbidity
  • Diabetes Mellitus, Type 2 / mortality*
  • Dietary Fats
  • Follow-Up Studies
  • Humans
  • Hypertension / epidemiology
  • Incidence
  • Male
  • Middle Aged
  • Motor Activity*
  • Multivariate Analysis
  • Prevalence
  • Proportional Hazards Models
  • Prospective Studies
  • Risk
  • Risk Assessment
  • Smoking / epidemiology
  • United States / epidemiology
  • Walking


  • Dietary Fats