Atypical meningioma and extensive calvarium defects in neurofibromatosis type 1

Pediatr Radiol. 2003 Aug;33(8):551-3. doi: 10.1007/s00247-003-0927-4. Epub 2003 Apr 26.


A 9-year-old girl with neurofibromatosis type 1 (NF1) presented with a massive atypical meningioma and calvarial defect. Skull radiographs and cranial CT showed an extensive lytic bone lesion at the vertex. MRI demonstrated a large mass invading the calvarium and sagittal sinus. The histopathological and immunohistochemical diagnosis of the resected mass was atypical meningioma. To our knowledge, this is the first case of NF1 associated with atypical meningioma and massive calvarial defect in a child.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Meningioma / diagnosis
  • Meningioma / etiology*
  • Neurofibromatosis 1 / complications*
  • Skull Neoplasms / diagnosis
  • Skull Neoplasms / etiology*
  • Tomography, X-Ray Computed