B7-H1 pathway and its role in the evasion of tumor immunity

J Mol Med (Berl). 2003 May;81(5):281-7. doi: 10.1007/s00109-003-0430-2. Epub 2003 Apr 30.


B7-H1 is a recently identified member of the B7 family molecules. Upon ligation to its receptors on T cells it regulates activation and differentiation of T cells. B7-H1 preferentially costimulates IL-10 production in resting T cells and further induces the apoptosis of activated T cells. PD-1 is a receptor of B7-H1 and is shown to mediate the inhibition of activated T cell response, presumably by inhibiting cell cycle progression. The expression of B7-H1 protein is limited to macrophage lineage of cells in normal tissues, although its mRNA transcription is found in a broad range of tissues. In contrast, B7-H1 is abundant in various human cancers. The tumor-associated B7-H1 increases apoptosis of antigen specific T cells, leading to growth of immunogenic tumor growth in vivo. Current data suggest that B7-H1 regulates the organ-specific tolerance in normal tissue and may contribute to immune evasion by cancers. Selective manipulation of B7-H1 pathway thus aids in the design of new regimens in the treatment of human autoimmune disease and the control of malignant cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens, CD
  • B7-1 Antigen / chemistry
  • B7-1 Antigen / metabolism
  • B7-1 Antigen / physiology*
  • B7-H1 Antigen
  • Blood Proteins*
  • Colonic Neoplasms / immunology
  • Female
  • Humans
  • Immune Tolerance
  • Membrane Glycoproteins
  • Models, Immunological
  • Neoplasms / immunology*
  • Neoplasms / therapy
  • Ovarian Neoplasms / immunology
  • Peptides*
  • Receptors, Immunologic / physiology
  • Signal Transduction
  • T-Lymphocytes / immunology


  • Antigens, CD
  • B7-1 Antigen
  • B7-H1 Antigen
  • Blood Proteins
  • CD274 protein, human
  • Membrane Glycoproteins
  • Peptides
  • Receptors, Immunologic