Antiangiogenic activity of lupeol from Bombax ceiba

Phytother Res. 2003 Apr;17(4):341-4. doi: 10.1002/ptr.1140.

Abstract

In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / pharmacology*
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Bombax*
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / drug effects*
  • Humans
  • Mice
  • Neovascularization, Pathologic / metabolism
  • Pentacyclic Triterpenes
  • Phytotherapy*
  • Plant Bark
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Triterpenes / administration & dosage
  • Triterpenes / pharmacology*
  • Triterpenes / therapeutic use
  • Tumor Cells, Cultured / drug effects

Substances

  • Angiogenesis Inhibitors
  • Pentacyclic Triterpenes
  • Plant Extracts
  • Triterpenes
  • lupeol