Abstract
In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.
Copyright 2003 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / pharmacology*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Bombax*
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Dose-Response Relationship, Drug
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Endothelium, Vascular / drug effects*
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Humans
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Mice
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Neovascularization, Pathologic / metabolism
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Pentacyclic Triterpenes
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Phytotherapy*
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Plant Bark
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Triterpenes / administration & dosage
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Triterpenes / pharmacology*
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Triterpenes / therapeutic use
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Tumor Cells, Cultured / drug effects
Substances
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Angiogenesis Inhibitors
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Pentacyclic Triterpenes
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Plant Extracts
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Triterpenes
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lupeol