Pemetrexed (Alimta): a novel multitargeted antifolate agent

Expert Rev Anticancer Ther. 2003 Apr;3(2):145-56. doi: 10.1586/14737140.3.2.145.

Abstract

Pemetrexed (Alimta) is a novel, multitargeted antifolate that inhibits at least three of the enzymes involved in folate metabolism, and purine and pyrimidine synthesis. These enzymes are thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. Pemetrexed has demonstrated broad antitumor activity in Phase II trials in a wide variety of solid tumors, including mesothelioma, non-small cell lung, breast, cervical, colorectal, head and neck, and bladder cancers. Promising activity has also been demonstrated when pemetrexed is combined with cisplatin and gemcitabine (Gemzar). A pivotal Phase III study in mesothelioma has been presented. This study indicates the superiority of pemetrexed in combination with cisplatin versus cisplatin alone in this disease. The most significant toxicities of pemetrexed, myelosuppression and mucositis have been significantly ameliorated by folate and vitamin B12 supplementation. More importantly, vitamin supplementation has not demonstrated any adverse efficacy. This review discusses the biochemistry and clinical activity of pemetrexed.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use*
  • Folic Acid Antagonists / adverse effects
  • Folic Acid Antagonists / pharmacokinetics
  • Folic Acid Antagonists / therapeutic use*
  • Glutamates / adverse effects
  • Glutamates / pharmacokinetics
  • Glutamates / therapeutic use*
  • Guanine / adverse effects
  • Guanine / analogs & derivatives*
  • Guanine / pharmacokinetics
  • Guanine / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Pemetrexed
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Folic Acid Antagonists
  • Glutamates
  • Pemetrexed
  • Guanine