Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray

Ann Allergy Asthma Immunol. 2003 Apr;90(4):416-21. doi: 10.1016/S1081-1206(10)61826-1.


Background: Cough commonly occurs as a symptom of seasonal allergic rhinitis (SAR), an inflammatory condition of the nasal mucous membranes that results in rhinorrhea, nasal stuffiness/congestion, nasal itching, and sneezing. Mometasone furoate nasal spray (MFNS, Nasonex, Schering, Kenilworth, NJ), an anti-inflammatory nasal corticosteroid, has been shown to be safe and effective in reducing the nasal inflammation of SAR.

Objective: To examine the effectiveness of MFNS in relieving SAR-associated cough, in addition to nasal symptoms.

Methods: This was a multicenter, randomized, double-blind study. Patients 12 years of age or older with > or = 1-year history of SAR symptoms, positive skin test to a prevailing seasonal allergen, moderate nasal symptoms, and moderate cough were treated for 14 days with MFNS 200 microg daily (n = 122) or placebo (n = 123).

Results: The group treated with MFNS showed significant improvement in the daytime cough severity score at endpoint compared with placebo (P = 0.049). Improvement in the nighttime cough severity score showed a trend in favor of MFNS treatment. Treatment with MFNS significantly improved total nasal symptoms in both the daytime and nighttime compared with placebo at endpoint (P < or = 0.017). Overall daytime symptom scores (cough + total nasal) improved significantly compared with placebo at endpoint (P = 0.005). Overall nighttime symptom scores improved significantly compared with placebo at endpoint (P = 0.028). Treatments were well tolerated, with no significant differences in the incidence of adverse events.

Conclusions: MFNS is effective and well tolerated in the treatment of daytime cough associated with SAR.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intranasal
  • Adolescent
  • Adult
  • Aerosols
  • Aged
  • Anti-Allergic Agents / administration & dosage
  • Anti-Allergic Agents / therapeutic use*
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Child
  • Cough / drug therapy*
  • Cough / etiology
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mometasone Furoate
  • Nasal Decongestants / administration & dosage
  • Nasal Decongestants / therapeutic use*
  • Nasal Obstruction / drug therapy*
  • Nasal Obstruction / etiology
  • Pregnadienediols / administration & dosage
  • Pregnadienediols / therapeutic use*
  • Pruritus / drug therapy*
  • Pruritus / etiology
  • Rhinitis, Allergic, Seasonal / complications*
  • Rhinitis, Allergic, Seasonal / drug therapy
  • Safety
  • Sneezing / drug effects*
  • Treatment Outcome


  • Aerosols
  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Nasal Decongestants
  • Pregnadienediols
  • Mometasone Furoate