Epigenetics in carcinogenesis and cancer prevention

Ann N Y Acad Sci. 2003 Mar;983:213-9. doi: 10.1111/j.1749-6632.2003.tb05976.x.


Carcinogenesis is a stepwise process of accumulation of genetic and epigenetic abnormalities that can lead to cellular dysfunction. It has become clear that epigenetic changes are equally important for this multistep process to produce its results. This article describes the different roles that epigenetic modulation may play during carcinogenesis and how an early detection and chemopreventive intervention strategy that takes both sides of the equation into account would be advantageous.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic*
  • CpG Islands / genetics
  • DNA Methylation
  • DNA Replication
  • Gene Silencing
  • Genes, Tumor Suppressor
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neoplasms / prevention & control
  • Transcription, Genetic