Aberrant DNA methylation in ovarian cancer: is there an epigenetic predisposition to drug response?

Ann N Y Acad Sci. 2003 Mar;983:243-50. doi: 10.1111/j.1749-6632.2003.tb05979.x.

Abstract

Epigenetic regulation of gene expression has been observed in a variety of tumor types. We have used microarray technology to evaluate the predisposition of drug response by aberrant methylation in ovarian cancer. Results indicate that loss of gene activity due to hypermethylation potentially confers a predisposition in certain cancer types and is an early event in disease progression. Methylation profiles of ovarian cancer might be useful for early cancer detection and prediction of chemotherapy outcome in a clinical context.

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Blotting, Southern
  • CpG Islands / genetics
  • DNA Methylation*
  • Female
  • Humans
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / genetics*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents