Cancer revoked: oncogenes as therapeutic targets

Nat Rev Cancer. 2003 May;3(5):375-80. doi: 10.1038/nrc1070.


Recent findings show that even the brief inactivation of a single oncogene might be sufficient to result in the sustained loss of a neoplastic phenotype. It is therefore possible that the targeted inactivation of oncogenes could be a specific and effective treatment for cancer. So why does oncogene inactivation cause tumour regression and will this be a generally successful approach for the treatment of human neoplasia?

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / therapy*
  • Oncogenes*