Analysis of the mitochondrial genome in sudden infant death syndrome

Acta Paediatr. 2003;92(3):386-8. doi: 10.1080/08035250310009338.


Aim: To investigate the mitochondrial genome and its association with sudden infant death syndrome (SIDS).

Methods: Twenty SIDS infants were screened for previously reported mitochondrial DNA mutations using direct sequencing. The whole mitochondrial genome was also sequenced for six of the infants.

Results: Three substitutions, A11467G, A12308G and G12372A, comprising a haplogroup were present in four infants diagnosed as pure SIDS. This haplogroup was also common in a control group.

Conclusions: No specific mutation or polymorphism was found in association with SIDS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Mutational Analysis
  • DNA, Mitochondrial / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genome, Human*
  • Haplotypes / genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Polymorphism, Genetic / genetics
  • Sudden Infant Death / etiology
  • Sudden Infant Death / genetics*


  • DNA, Mitochondrial