Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 3 (4), 311-6

Emerging Roles for E2F: Beyond the G1/S Transition and DNA Replication

Affiliations
Review

Emerging Roles for E2F: Beyond the G1/S Transition and DNA Replication

Hugh Cam et al. Cancer Cell.

Abstract

E2F activity is crucial for the G1/S transition and DNA replication in mammalian cells. The retinoblastoma (pRB) family of proteins is the primary negative regulator of E2F. Recent findings have begun to clarify distinct roles for E2F family members during cell cycle progression and have considerably broadened our understanding of E2F transcriptional control beyond S phase. In this review, we examine the relative contribution of two distinct subclasses of E2F to repression and activation and how this division of labor could explain the role of E2F in DNA damage and repair checkpoints as well as tumorigenesis.

Similar articles

See all similar articles

Cited by 107 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback