Genetic associations: false or true?

Trends Mol Med. 2003 Apr;9(4):135-8. doi: 10.1016/s1471-4914(03)00030-3.


Genetic association studies for multigenetic diseases are like fishing for the truth in a sea of trillions of candidate analyses. Red herrings are unavoidably common, and bias might cause serious misconceptions. However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false.

Publication types

  • Review

MeSH terms

  • Genetic Predisposition to Disease*
  • Genetics, Medical
  • Humans
  • Meta-Analysis as Topic*
  • Polymorphism, Genetic