Protein carbonylation in human diseases

Trends Mol Med. 2003 Apr;9(4):169-76. doi: 10.1016/s1471-4914(03)00031-5.


Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis. Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants / metabolism
  • Antioxidants / therapeutic use
  • Disease*
  • Humans
  • Oxidation-Reduction
  • Oxidative Stress*
  • Proteins / chemistry
  • Proteins / metabolism*
  • Reactive Oxygen Species / metabolism


  • Antioxidants
  • Proteins
  • Reactive Oxygen Species