Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement

Eur Heart J. 2003 May;24(9):820-7. doi: 10.1016/s0195-668x(02)00824-2.


Aims: Endothelial nitric oxide synthase (eNOS) catalyzes the formation of nitric oxide which has vasodilatory, antithrombotic, antiinflammatory and antiproliferative properties. The TT genotype of the single nucleotide polymorphism 894 G/T, located in exon 7 of the eNOS gene, was found to be associated with coronary spasm, coronary artery disease (CAD) and myocardial infarction (MI). We investigated the possibility that the 894 TT genotype has an unfavorable impact on the angiographic and clinical outcome after the placement of stents in coronary arteries.

Methods and results: Our study included 1850 patients with CAD who were treated with stent implantation. Major adverse clinical events, including death, MI, and target vessel revascularization, were recorded for 1 year after the intervention. Patients with genotype 894 TT had an increase in the risk of death or MI (hazard ratio 2.14, 95% confidence interval (CI) 1.23-3.72; p=0.007), if compared with G allele carriers. TT patients showed no significant increase in the risk for angiographic restenosis (odds ratio (OR) 1.11, 95% CI 0.78-1.56; p=0.56) and target vessel revascularization (OR 1.21, 95% CI 0.82-1.78; p=0.34).

Conclusions: In comparison with eNOS 894 G allele carriers, patients of the TT genotype were at an increased risk of death or MI within 1 year after coronary artery stenting.

MeSH terms

  • Acute Disease
  • Coronary Angiography
  • Coronary Artery Disease / enzymology*
  • Coronary Artery Disease / therapy
  • Coronary Stenosis / etiology
  • Coronary Thrombosis / etiology
  • Coronary Vasospasm / enzymology*
  • Female
  • Genotype
  • Homozygote
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / enzymology*
  • Nitric Oxide Synthase / genetics*
  • Nitric Oxide Synthase Type III
  • Risk Factors
  • Stents*


  • NOS3 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III