Mapping functional residues onto integrin crystal structures

Curr Opin Struct Biol. 2003 Apr;13(2):236-43. doi: 10.1016/s0959-440x(03)00035-6.


Historical data, available in the literature, concerning the sites responsible for integrin-ligand binding and activation may now be transposed onto recently solved crystal structures of integrin dimers and functional domains. The data were obtained through studies of natural and engineered mutations within integrins, and analyses of the epitopes for function-altering monoclonal antibodies. In the past two years, this combining of structure and function has led to the development of novel hypotheses for the mechanisms of integrin regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Crystallography / methods*
  • Epitope Mapping
  • Integrins / chemistry*
  • Integrins / metabolism*
  • Ligands
  • Models, Molecular*
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Protein Subunits
  • Structure-Activity Relationship*


  • Integrins
  • Ligands
  • Protein Subunits