The role of relB in regulating the adaptive immune response

Ann N Y Acad Sci. 2003 Apr;987:249-57. doi: 10.1111/j.1749-6632.2003.tb06056.x.

Abstract

Dendritic cells (DCs), which represent a key type of antigen-presenting cell (APC), are important for the development of innate and adaptive immunity. DCs are involved in T cell activation in at least two main ways: priming via direct processing/presentation of soluble antigen taken up from the microenvironment (conventional priming), and processing/presentation of antigen released from other cells (cross-priming). relB, a component of the NF-kappaB complex of transcription factors, is a critical regulator of the differentiation of DCs. In mice, lack of relB impairs DCs derived from bone marrow both in number and function. Here relB (-/-) bone marrow chimera mice is used to study the APC function of residual DCs in presentation of soluble antigen and cross-priming. It is found that the DCs in these mice are profoundly deficient in their ability to both prime and cross-prime T cell responses. It was concluded that the relB gene is involved in regulating the APC function of DCs in vivo.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Animals
  • Immunity, Cellular / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Proto-Oncogene Proteins / physiology*
  • T-Lymphocytes, Cytotoxic / immunology
  • Transcription Factor RelB
  • Transcription Factors / physiology*

Substances

  • Proto-Oncogene Proteins
  • Relb protein, mouse
  • Transcription Factors
  • Transcription Factor RelB