Who's on first in the cellular response to DNA damage?

Nat Rev Mol Cell Biol. 2003 May;4(5):361-72. doi: 10.1038/nrm1101.


Cellular DNA-repair pathways involve proteins that have roles in other DNA-metabolic processes, as well as those that are dedicated to damage removal. Several proteins, which have diverse functions and are not known to have roles in DNA repair, also associate with damaged DNA. These newly discovered interactions could either facilitate or hinder the recognition of DNA damage, and so they could have important effects on DNA repair and genetic integrity. The outcome for the cell, and ultimately for the organism, might depend on which proteins arrive first at sites of DNA damage.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA / chemistry
  • DNA / metabolism
  • DNA Damage*
  • DNA Ligases / metabolism
  • DNA Repair
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Eukaryotic Cells / metabolism
  • Humans
  • Models, Biological
  • Models, Genetic
  • Transcription, Genetic


  • DNA-Binding Proteins
  • DNA
  • DNA Ligases