Ras proteins: different signals from different locations

Nat Rev Mol Cell Biol. 2003 May;4(5):373-84. doi: 10.1038/nrm1105.


Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Conserved Sequence
  • Endoplasmic Reticulum / metabolism
  • GTP-Binding Proteins / metabolism
  • Golgi Apparatus / metabolism
  • Humans
  • Membrane Microdomains / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Models, Biological
  • Protein Structure, Tertiary
  • Signal Transduction*
  • ras Proteins / chemistry
  • ras Proteins / metabolism*


  • Membrane Proteins
  • GTP-Binding Proteins
  • ras Proteins