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Review
. 2003 May;4(5):397-407.
doi: 10.1038/nrm1103.

Sphingosine-1-phosphate: An Enigmatic Signalling Lipid

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Review

Sphingosine-1-phosphate: An Enigmatic Signalling Lipid

Sarah Spiegel et al. Nat Rev Mol Cell Biol. .

Abstract

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

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