Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 May;4(5):397-407.
doi: 10.1038/nrm1103.

Sphingosine-1-phosphate: An Enigmatic Signalling Lipid


Sphingosine-1-phosphate: An Enigmatic Signalling Lipid

Sarah Spiegel et al. Nat Rev Mol Cell Biol. .


The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

Similar articles

See all similar articles

Cited by 651 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources