Sphingosine-1-phosphate: an enigmatic signalling lipid

Nat Rev Mol Cell Biol. 2003 May;4(5):397-407. doi: 10.1038/nrm1103.

Abstract

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Calcium / metabolism
  • Cell Movement
  • GTP-Binding Proteins / metabolism
  • Humans
  • Ligands
  • Lipid Metabolism*
  • Lysophospholipids*
  • Models, Biological
  • Plants / genetics
  • Plants / metabolism
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled*
  • Receptors, Lysophospholipid
  • Signal Transduction*
  • Sphingolipids / metabolism
  • Sphingosine / analogs & derivatives*
  • Sphingosine / genetics
  • Sphingosine / metabolism
  • Sphingosine / physiology*
  • Transcriptional Activation

Substances

  • Ligands
  • Lysophospholipids
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophospholipid
  • Sphingolipids
  • sphingosine 1-phosphate
  • GTP-Binding Proteins
  • Sphingosine
  • Calcium