Coat proteins: shaping membrane transport

Nat Rev Mol Cell Biol. 2003 May;4(5):409-14. doi: 10.1038/nrm1099.

Abstract

Coat proteins allow the selective transfer of macromolecules from one membrane-enclosed compartment to another by concentrating macromolecules into specialized membrane patches and then deforming these patches into small coated vesicles. Recent findings indicate that coat proteins might also participate in the differentiation of membrane domains within organelles and large transport carriers, as well as in the association of the carriers with the cytosketelon and with acceptor organelles.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport*
  • Capsid Proteins / chemistry
  • Capsid Proteins / metabolism*
  • Coated Pits, Cell-Membrane / metabolism
  • Coated Pits, Cell-Membrane / ultrastructure
  • Coated Vesicles / metabolism
  • Coated Vesicles / ultrastructure
  • Endoplasmic Reticulum / metabolism
  • Endoplasmic Reticulum / ultrastructure
  • Endosomes / metabolism
  • Endosomes / ultrastructure
  • Eukaryotic Cells / metabolism
  • Golgi Apparatus / metabolism
  • Humans
  • Kinetics
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology*
  • Models, Biological
  • Recombinant Proteins / metabolism

Substances

  • Capsid Proteins
  • Membrane Proteins
  • Recombinant Proteins