Caenorhabditis elegans: an emerging genetic model for the study of innate immunity

Nat Rev Genet. 2003 May;4(5):380-90. doi: 10.1038/nrg1067.


Invaluable insights into how animals, humans included, defend themselves against infection have been provided by more than a decade of genetic studies that have used fruitflies. In the past few years, attention has also turned to another simple animal model, the nematode worm Caenorhabditis elegans. What exactly have we learned from the work in Drosophila? And will research with C. elegans teach us anything new about our response to pathogen attack?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / immunology*
  • Drosophila melanogaster / immunology
  • Immunity, Innate / genetics
  • Models, Genetic*
  • Signal Transduction