Growing evidence for diabetes susceptibility genes from genome scan data

Curr Diab Rep. 2003 Apr;3(2):159-67. doi: 10.1007/s11892-003-0040-y.


Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain-10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing*
  • Genome, Human*
  • Humans