Immune restoration disorders following HAART

AIDS Read. 1999 May-Jun;9(3):167-9.


Highly active antiretroviral therapy (HAART) leads to a profound and sustained suppression of viral replication, along with a rise in CD4+ cells in most HIV-infected patients. However, reports are accumulating of growing numbers of patients suffering from opportunistic infections despite recovery of CD4+ cells and plummeting viral loads as part of a new syndrome called immune restoration disease. We describe this syndrome in two patients and review the current literature.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / etiology*
  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • CD4 Lymphocyte Count*
  • Female
  • Humans
  • Male
  • Viral Load