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. 2003 May 19;13(10):1687-90.
doi: 10.1016/s0960-894x(03)00242-7.

Synthesis of Beta-Lactamase Activated Nitric Oxide Donors

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Synthesis of Beta-Lactamase Activated Nitric Oxide Donors

Xiaoping Tang et al. Bioorg Med Chem Lett. .

Abstract

In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.

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