The Maudsley early onset schizophrenia study: cognitive function in adolescents with recent onset schizophrenia

Schizophr Res. 2003 Jun 1;61(2-3):137-48. doi: 10.1016/s0920-9964(02)00291-8.


Neuropsychological function has been little studied early in the course of adolescent onset schizophrenia. The present study investigated cognitive function in adolescents with recent onset schizophrenia (n=20) and healthy controls (n=21), employing a comprehensive battery of intelligence, memory and executive function paradigms. Relative to the control group, the patients showed significant or near-significant deficits in more than half of the cognitive variables we examined. A substantial proportion of this broadly based neuropsychological deficit could be accounted for, at least in part, by a mild decrement in general intellectual ability. However, deficits in general and verbal memory remained highly significant after co-varying for IQ.

MeSH terms

  • Adolescent
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Female
  • Humans
  • Intelligence
  • Male
  • Neuropsychological Tests / statistics & numerical data*
  • Psychometrics
  • Schizophrenia / diagnosis*
  • Schizophrenic Psychology*