Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour

Eur Neuropsychopharmacol. 2003 May;13(3):137-45. doi: 10.1016/s0924-977x(02)00175-x.


This study aimed to explore the effects of melatonin on sleep, waking up and well being in subjects with varying degrees of seasonal or weather-associated changes in mood and behaviour. Fifty-eight healthy adults exhibiting subsyndromal seasonal affective disorder (s-SAD) and/or the negative or positive type of weather-associated syndrome (WAS) were randomised to either 2 mg of sustained-release melatonin or placebo tablets 1-2 h before a desired bedtime for 3 weeks. Outcome measures were changes from baseline in sleep quality, sleepiness after waking, atypical depressive symptoms and health-related quality of life by week three. Early morning salivary melatonin concentrations were measured at baseline and treatment cessation in all subjects. Melatonin administration significantly improved the quality of sleep (P=0.03) and vitality (P=0.02) in the subjects with s-SAD, but attenuated the improvement of atypical symptoms and physical parameters of quality of life compared to placebo in the subjects with WAS, positive type.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Affect / drug effects*
  • Circadian Rhythm / drug effects
  • Delayed-Action Preparations
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Melatonin / administration & dosage*
  • Melatonin / pharmacokinetics
  • Melatonin / therapeutic use*
  • Middle Aged
  • Quality of Life / psychology*
  • Saliva / metabolism
  • Seasonal Affective Disorder / drug therapy*
  • Seasonal Affective Disorder / psychology
  • Sleep / drug effects*
  • Treatment Outcome
  • Weather*


  • Delayed-Action Preparations
  • Melatonin