The Na/K pump, Cl ion, and osmotic stabilization of cells

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6257-62. doi: 10.1073/pnas.0931278100. Epub 2003 May 1.

Abstract

An equation for membrane voltage is derived that takes into account the electrogenicity of the Na/K pump and is valid dynamically, as well as in the steady state. This equation is incorporated into a model for the osmotic stabilization of cells. The results emphasize the role of the pump and membrane voltage in lowering internal Cl(-) concentration, thus making osmotic room for vital substances that must be sequestered in the cell.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anions
  • Cell Membrane / enzymology
  • Cell Membrane / physiology
  • Cell Membrane Permeability / physiology*
  • Cell Physiological Phenomena*
  • Chlorides / metabolism*
  • Electrophysiology
  • Kinetics
  • Models, Biological
  • Muscle, Skeletal / physiology*
  • Osmolar Concentration
  • Ranidae
  • Reproducibility of Results
  • Sodium-Potassium-Exchanging ATPase / metabolism*

Substances

  • Anions
  • Chlorides
  • Sodium-Potassium-Exchanging ATPase