Abstract
An equation for membrane voltage is derived that takes into account the electrogenicity of the Na/K pump and is valid dynamically, as well as in the steady state. This equation is incorporated into a model for the osmotic stabilization of cells. The results emphasize the role of the pump and membrane voltage in lowering internal Cl(-) concentration, thus making osmotic room for vital substances that must be sequestered in the cell.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anions
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Cell Membrane / enzymology
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Cell Membrane / physiology
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Cell Membrane Permeability / physiology*
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Cell Physiological Phenomena*
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Chlorides / metabolism*
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Electrophysiology
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Kinetics
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Models, Biological
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Muscle, Skeletal / physiology*
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Osmolar Concentration
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Ranidae
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Reproducibility of Results
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Sodium-Potassium-Exchanging ATPase / metabolism*
Substances
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Anions
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Chlorides
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Sodium-Potassium-Exchanging ATPase