Weight loss in Parkinson's disease

Ann Neurol. 2003 May;53(5):676-9. doi: 10.1002/ana.10577.


We prospectively examined the changes of body weight among 468 individuals with Parkinson's disease (PD) before and after the diagnosis. The average weight of PD patients was stable until shortly before the diagnosis (p for trend = 0.2) and then declined (p for trend < 0.0001). Interestingly, PD patients tended to increase their energy intakes as their weights decreased (p for trend < 0.002). In conclusion, weight loss in PD patients appears to be a continuous process that starts several years before the diagnosis and is not caused by reduced energy intake.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Energy Intake / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Weight Loss / physiology*