Coupling the initiation of chromosome replication to cell size in Escherichia coli

Curr Opin Microbiol. 2003 Apr;6(2):146-50. doi: 10.1016/s1369-5274(03)00026-2.


Bacterial cells change size dramatically with change in growth rate, but the ratio between cell volume and the number of copies of the origin of chromosome replication (oriC) is roughly constant at the time of initiation of DNA replication at almost all growth rates. Recent research on the inactivation of initiator protein (DnaA) and depletion of DnaA pools by the high-affinity DnaA-binding locus datA allows us to propose a simple model to explain the long-standing question of how Escherichia coli couples DNA replication to cell size.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Bacterial Proteins / metabolism
  • Chromosomes, Bacterial*
  • DNA Replication
  • DNA, Bacterial / genetics
  • DNA-Binding Proteins / metabolism
  • Escherichia coli / genetics*
  • Escherichia coli / growth & development
  • Models, Genetic


  • Bacterial Proteins
  • DNA, Bacterial
  • DNA-Binding Proteins
  • DnaA protein, Bacteria
  • Adenosine Triphosphate