Plant cell factories and mucosal vaccines

Curr Opin Biotechnol. 2003 Apr;14(2):145-50. doi: 10.1016/s0958-1669(03)00026-0.


Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown to protect against challenge in the target host. Increased antigen expression levels (up to 4.1% total soluble protein) have been obtained through transformation of the chloroplast genome. In view of these findings, plant-derived vaccines have been proved as valuable commodities to the world's health system; however, before their application, studies need to focus on optimization of immunization strategies and to investigate antigen stability.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Bacterial Vaccines
  • Drug Stability
  • Gene Expression Regulation, Plant*
  • Genetic Engineering / methods*
  • Humans
  • Immunity, Mucosal / immunology
  • Plants, Genetically Modified / genetics*
  • Plants, Genetically Modified / immunology
  • Plants, Genetically Modified / virology*
  • Recombinant Fusion Proteins / administration & dosage
  • Recombinant Fusion Proteins / biosynthesis
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / immunology
  • Transformation, Genetic
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / biosynthesis*
  • Vaccines, Synthetic / genetics*
  • Viral Vaccines


  • Bacterial Vaccines
  • Recombinant Fusion Proteins
  • Vaccines, Synthetic
  • Viral Vaccines