[Expression of C-myc and N-myc protein in adulthood and childhood medulloblastomas and prognostic analysis]

Hua Xi Yi Ke Da Xue Xue Bao. 2001 Mar;32(1):120-2.
[Article in Chinese]

Abstract

Objective: To detect the expression of C-myc and N-myc in medulloblastomas, the difference between adults and children, and the relation between expression and prognosis.

Methods: ABC immunostaining was used to detect C-myc and N-myc protein expression in 21 cases of adulthood medulloblastomas and 14 childhood cases. Follow-up materials were obtained to perform survival curve analysis.

Results: Of these 35 cases, 5 (4 children, 1 adult) showed C-myc positive expression. No N-myc expression was found. There was no relationship between expression and survival.

Conclusion: C-myc may play a role in the tumorgenesis of medulloblastoma, especially in children, but it is of no prognostic significance. N-myc antigen may be lost during the fixation of specimens.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Cerebellar Neoplasms / metabolism*
  • Child
  • Child, Preschool
  • Follow-Up Studies
  • Humans
  • Medulloblastoma / metabolism*
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-myc / biosynthesis*

Substances

  • Proto-Oncogene Proteins c-myc