Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

Genome Biol. 2003;4(5):111. doi: 10.1186/gb-2003-4-5-111. Epub 2003 Apr 29.

Abstract

Protein kinases with a conserved catalytic domain make up one of the largest 'superfamilies' of eukaryotic proteins and play many key roles in biology and disease. Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data.

MeSH terms

  • Catalysis
  • Catalytic Domain / genetics
  • Databases, Nucleic Acid
  • Genome, Human*
  • Humans
  • Multigene Family / genetics*
  • Phosphorylation
  • Protein Kinases / genetics*
  • Protein Kinases / metabolism
  • Substrate Specificity

Substances

  • Protein Kinases