A novel exploratory method for visual recombination detection

Genome Biol. 2003;4(5):R33. doi: 10.1186/gb-2003-4-5-r33. Epub 2003 Apr 25.

Abstract

A versatile visual approach for detecting recombination and identifying recombination breakpoints within a sequence alignment is presented. The method is based on two novel diagrams - the highway plot and the occupancy plot - that graphically portray phylogenetic inhomogeneity along an alignment, and can be viewed as a synthesis of two widely used but unrelated methods: bootscanning and quartet-mapping. To illustrate the method, simulated data and HIV-1 and influenza A datasets are investigated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology / methods*
  • Computer Simulation
  • Databases, Genetic
  • HIV-1 / genetics
  • Humans
  • Models, Genetic
  • Orthomyxoviridae / genetics
  • Phylogeny
  • Recombination, Genetic / genetics*
  • Sequence Alignment / methods