Effect of ICSI on subsequent blastocyst development and pregnancy rates

J Assist Reprod Genet. 2003 Mar;20(3):113-6. doi: 10.1023/a:1022678807398.


Purpose: To investigate whether ICSI (intracytoplasmic sperm injection) results in decreased blastocyst formation and pregnancy compared to IVF (in vitro fertilization).

Methods: We performed a retrospective analysis of blastocyst transfer (BT) offered routinely to patients under age 40 with > or = three 8-cell embryos on day 3 and compared IVF to ICSI cycles. Sequential media were used with P1 until day 3, then Blastocyst Medium until day 5/6.

Results: There were 131 IVF and 75 ICSI cycles. There was no difference in age, number of oocytes, zygotes, 8-cell embryos, blastocysts on days 5 and 6, or embryos transferred. Progression to blastocyst was similar (78% for IVF and 73% for ICSI) as was the viable pregnancy rate (51.4% for IVF and 55% for ICSI). No cycles failed to form blastocysts.

Conclusions: The progression to blastocyst and the likelihood of conceiving a viable pregnancy were unaltered by ICSI. Thus it seems appropriate for programs to offer BT to patients undergoing ICSI using the same inclusion criteria applied to their IVF patients.

MeSH terms

  • Adult
  • Blastocyst*
  • Female
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Rate*
  • Sperm Injections, Intracytoplasmic*