Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissue

Science. 1976 May 28;192(4242):907-8. doi: 10.1126/science.1273576.

Abstract

Vasoactive intestinal polypeptide immunoreactivity is present in high concentrations in clonal lines of neuronal and glial origin. The central nervous system and sympathetic ganglia are also rich in the peptide. The findings suggest that this peptide, hitherto thought limited to the gastrointestinal tract, is widely distributed in neural tissue and may have broad physiological significance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Cell Line
  • Cerebral Cortex / analysis
  • Dogs
  • Gastrointestinal Hormones / analysis
  • Glioma
  • Nerve Tissue Proteins / analysis*
  • Neuroblastoma
  • Neuroglia / analysis*
  • Neurons / analysis*
  • Peptides / analysis*
  • Peptides / immunology
  • Radioimmunoassay

Substances

  • Gastrointestinal Hormones
  • Nerve Tissue Proteins
  • Peptides