Diabetic kidney disease in the db/db mouse

Am J Physiol Renal Physiol. 2003 Jun;284(6):F1138-44. doi: 10.1152/ajprenal.00315.2002.


Diabetic nephropathy is increasing in incidence and is now the number one cause of end-stage renal disease in the industrialized world. To gain insight into the genetic susceptibility and pathophysiology of diabetic nephropathy, an appropriate mouse model of diabetic nephropathy would be critical. A large number of mouse models of diabetes have been identified and their kidney disease characterized to various degrees. Perhaps the best characterized and most intensively investigated model is the db/db mouse. Because this model appears to exhibit the most consistent and robust increase in albuminuria and mesangial matrix expansion, it has been used as a model of progressive diabetic renal disease. In this review, we present the findings from various studies on the renal pathology of the db/db mouse model of diabetes in the context of human diabetic nephropathy. Furthermore, we discuss shortfalls of assessing functional renal disease in mouse models of diabetic kidney disease.

Publication types

  • Review

MeSH terms

  • Albuminuria / pathology
  • Animals
  • Blood Pressure / physiology
  • Diabetes Mellitus / genetics*
  • Diabetic Nephropathies / pathology*
  • Diabetic Nephropathies / physiopathology
  • Diabetic Nephropathies / therapy
  • Fluorescent Antibody Technique
  • Glomerular Mesangium / pathology
  • Hypertrophy
  • Kidney / pathology
  • Kidney Function Tests
  • Kidney Glomerulus / pathology
  • Mice