No association of inducible nitric oxide synthase gene ( NOS2A) to multiple sclerosis

J Neurol. 2003 May;250(5):598-600. doi: 10.1007/s00415-003-1047-7.

Abstract

Nitric oxide (NO) is a nonspecific inflammatory mediator that has been involved in the pathogenesis of multiple sclerosis (MS). The influence of the promoter polymorphism of inducible NO synthase gene ( NOS2A) on susceptibility and outcome was studied in 140 MS Spanish patients and 147 healthy controls matched for sex, age, and ethnicity. No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Chi-Square Distribution
  • Confidence Intervals
  • Cross-Sectional Studies
  • Female
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / enzymology
  • Multiple Sclerosis / genetics*
  • Nitric Oxide Synthase / genetics*
  • Nitric Oxide Synthase Type II
  • Odds Ratio
  • Polymorphism, Genetic / genetics

Substances

  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II