The role of laminin in embryonic cell polarization and tissue organization

Dev Cell. 2003 May;4(5):613-24. doi: 10.1016/s1534-5807(03)00128-x.


Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with beta1-integrins, dystroglycan, and other cell surface receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Basement Membrane / cytology
  • Basement Membrane / embryology
  • Cell Adhesion
  • Cell Polarity*
  • Epithelial Cells / cytology
  • Laminin / metabolism*
  • Stem Cells / cytology
  • Stem Cells / ultrastructure


  • Laminin