Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

Lancet. 2003 May 3;361(9368):1523-4. doi: 10.1016/s0140-6736(03)13172-8.


Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Haemophilus Infections / epidemiology
  • Haemophilus Infections / prevention & control
  • Haemophilus Vaccines / administration & dosage*
  • Haemophilus influenzae type b / immunology*
  • Humans
  • Immunization Schedule
  • Infant
  • United Kingdom / epidemiology
  • Vaccination*


  • Antibodies, Viral
  • Haemophilus Vaccines