Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects

Clin Diagn Lab Immunol. 2003 May;10(3):495-7. doi: 10.1128/cdli.10.3.495-497.2003.


The activation of coagulation has been shown to contribute to proinflammatory responses in animal and in vitro experiments. Here we report that the activation of coagulation in healthy human subjects by the administration of recombinant factor VIIa also elicits a small but significant increase in the concentrations of interleukin 6 (IL-6) and IL-8 in plasma. This increase was absent when the subjects were pretreated with recombinant nematode anticoagulant protein c2, the inhibitor of tissue factor-factor VIIa.

MeSH terms

  • Blood Coagulation / drug effects*
  • Factor VII / administration & dosage
  • Factor VII / antagonists & inhibitors
  • Factor VII / pharmacology*
  • Factor VIIa
  • Helminth Proteins / pharmacology
  • Humans
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Kinetics
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / pharmacology*


  • Helminth Proteins
  • Interleukin-6
  • Interleukin-8
  • Recombinant Proteins
  • anti-coagulant protein C2, Ancylostoma caninum
  • Factor VII
  • recombinant FVIIa
  • Factor VIIa