Hemispheric dissociation in access to the human semantic system

Neuron. 2003 May 8;38(3):499-506. doi: 10.1016/s0896-6273(03)00199-5.

Abstract

Patient studies suggest that speech and environmental sounds are differentially processed by the left and right hemispheres. Here, using functional imaging in normal subjects, we compared semantic processing of spoken words to equivalent processing of environmental sounds, after controlling for low-level perceptual differences. Words enhanced activation in left anterior and posterior superior temporal regions, while environmental sounds enhanced activation in a right posterior superior temporal region. This left/right dissociation was unchanged by different attentional/working memory contexts, but it was specific to tasks requiring semantic analysis. While semantic processing involves widely distributed networks in both hemispheres, our results support the hypothesis of a dual access route specific for verbal and nonverbal material, respectively.

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Brain Mapping
  • Cerebral Cortex / anatomy & histology
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiology*
  • Functional Laterality / physiology*
  • Humans
  • Language Tests
  • Nerve Net / anatomy & histology
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiology*
  • Neural Pathways / anatomy & histology
  • Neural Pathways / diagnostic imaging
  • Neural Pathways / physiology*
  • Semantics
  • Speech Perception / physiology*
  • Tomography, Emission-Computed
  • Verbal Behavior / physiology*