Abstract
One hundred seventy-six consecutive patients treated with IV tissue plasminogen activator (tPA) for acute ischemic stroke were examined prospectively, and orolingual angioedema was found in nine (5.1%; 95% CI 2.3 to 9.5). The reaction was typically mild, transient, and contralateral to the ischemic hemisphere. Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alberta / epidemiology
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Angioedema / chemically induced*
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Angioedema / etiology
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Angioedema / pathology
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Angiotensin-Converting Enzyme Inhibitors / adverse effects*
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Angiotensin-Converting Enzyme Inhibitors / pharmacology
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Antihypertensive Agents / adverse effects*
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Bradykinin / metabolism
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Brain Ischemia / complications
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Cerebral Cortex / blood supply
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Cerebral Cortex / physiopathology
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Drug Synergism
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Female
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Fibrinolytic Agents / adverse effects*
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Frontal Lobe / blood supply
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Frontal Lobe / physiopathology
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Humans
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Lysine Carboxypeptidase / metabolism
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Male
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Mouth / pathology
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Prospective Studies
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Stroke / complications
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Stroke / drug therapy*
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Tissue Plasminogen Activator / adverse effects*
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Tongue / pathology
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Fibrinolytic Agents
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Lysine Carboxypeptidase
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Tissue Plasminogen Activator
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Bradykinin