Oral vitamin B12 can change our practice

Postgrad Med J. 2003 Apr;79(930):218-20. doi: 10.1136/pmj.79.930.218.


Oral vitamin B12 can provide an effective alternative to intramuscular injections, so giving patients a choice and reducing costs in primary care. This study investigated the effectiveness, safety, and acceptability of oral vitamin B12 as replacement therapy in patients with vitamin B12 deficiency in a city general practice population. Forty patients previously maintained on vitamin B12 injections were given 1000 micro g of oral cyanocobalamin daily for up to 18 months. All the patients maintained satisfactory serum B12 levels and showed normal haematology and neurology. Compliance and acceptability was excellent. The time for a change in practice has indeed arrived.

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia, Pernicious / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Physical Examination
  • Professional Practice
  • Prospective Studies
  • Vitamin B 12 / administration & dosage*


  • Vitamin B 12