Specific immunotherapy with a standardized latex extract in allergic workers: a double-blind, placebo-controlled study

J Allergy Clin Immunol. 2003 May;111(5):985-94. doi: 10.1067/mai.2003.1390.


Background: Preventive measures have been proposed to reduce the risk of sensitization to natural rubber latex (NRL), but this is not always feasible.

Objective: The aim of this study was to determine the efficacy and safety of specific immunotherapy with a standardized latex extract in sensitized workers.

Methods: Twenty-four patients allergic to NRL with contact urticaria (n = 8) and rhinitis or asthma (n = 16) were included (16 in the active group and 8 in the placebo group). Treatment started in a cluster immunotherapy protocol, with injections every week for 3 months and then every other week for another 3 months.

Results: Patients in the active group had significantly lower values than patients in the placebo group in skin terms of reactivity to NRL (P <.01), rubbing test results (P =.047), and latex glove use test results (P =.046) after 6 months of treatment. There were no significant differences between the active and placebo groups in symptom scores, use of medication, self-assessment, or methacholine test results either before or after treatment. Differences in nasal and bronchial symptoms during specific inhalation challenges (P = not significant and P =.05, respectively) were observed in favor of the active group. In the active group 32 systemic reactions were observed (8% of doses), mostly during the build-up period, being more frequent in patients with respiratory symptoms (P =.004). All reactions responded promptly to treatment.

Conclusion: Clinical efficacy was shown mainly on cutaneous symptoms, although an improvement in rhinitis and asthma symptoms was also observed during specific inhalation challenges. Latex-specific immunotherapy might be a useful approach for the treatment of latex allergy in sensitized workers.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Female
  • Forced Expiratory Volume
  • Humans
  • Immunoglobulin E / blood
  • Immunotherapy* / adverse effects
  • Latex / immunology*
  • Latex Hypersensitivity / therapy*
  • Male
  • Middle Aged
  • Occupational Diseases / therapy*
  • Skin Tests


  • Latex
  • Immunoglobulin E