Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations

Neuroradiology. 2003 May;45(5):304-7. doi: 10.1007/s00234-003-0939-7. Epub 2003 Mar 18.


MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jacob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology*
  • Cerebral Cortex / pathology
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Diffusion Magnetic Resonance Imaging*
  • Disease Progression
  • Humans
  • Male
  • Middle Aged