Beta-cell expansion for therapeutic compensation of insulin resistance in type 2 diabetes

Int J Exp Diabesity Res. Jan-Mar 2003;4(1):1-5. doi: 10.1080/15438600303731.


Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in beta-cell function and in regulation of the beta-cell mass. beta-Cell transplantation, as well as approaches that replenish or preserve the endogenous beta-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / physiopathology*
  • Humans
  • Insulin Resistance*
  • Islets of Langerhans / anatomy & histology
  • Islets of Langerhans / physiopathology*