Serum zinc and alkaline phosphatase values in pediatric bone marrow transplantation patients

Pediatr Hematol Oncol. 2003 Jun;20(4):265-71.


Zinc (Zn) plays an important role in the maintenance of immune functions, including cellular/humoral immunity, and in the prevention of oxidative injury. Therefore, the maintenance of a normal Zn status may be important in bone marrow transplantation (BMT) patients. Serum Zn levels were determined in 35 children during the BMT period. In addition, as Zn-related factors, serum Cu levels and alkaline phosphatase (AP) activity were also measured. There was a significant decrease in Zn and AP values during the immediate post-transplant period (lowest at day +7) when compared to pre-BMT levels (p <.01). The patients who developed hypozincemia were more likely to be transplanted for a diagnosis of malignant disorder and were younger, and adverse events appeared to occur more frequently. This preliminary study suggests that maintaining a normal Zn status may be important in BMT patients and that Zn deficiency may be a risk factor for adverse events.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Alkaline Phosphatase / blood*
  • Biomarkers / blood
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Copper / blood
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Sensitivity and Specificity
  • Zinc / blood*


  • Biomarkers
  • Copper
  • Alkaline Phosphatase
  • Zinc