Basing on general pathophysiological data, the main outlines and principles of early rehabilitation of patients with acute disturbance of cerebral blood flow are considered. Clinical ENMG analysis of peripheral neuromuscular apparatus in 32 patients with right- and left-side location of the lesion in acute and early rehabilitation periods of ischemic stroke is presented. Different variants of ENMG interrelations between paretic and intact extremities and their correlations with functional rehabilitation degree are shown. Different sanogenetic mechanisms of movement functions rehabilitation in patients with right- and left-side lesions are hypothesized. The results of early rehabilitation of patients with stroke in neurological clinic of Russian State Medical University (General Municipal Hospital N20) are presented.