Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype

Oral Oncol. 2003 Jul;39(5):483-90. doi: 10.1016/s1368-8375(03)00008-3.

Abstract

The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles which are associated with altered EH activity and may be linked to increased risk for tobacco-related cancers. The objective was to examine the role of EH polymorphisms in orolaryngeal cancer risk. The prevalence of the EH codons 113 and 139 polymorphisms were examined in 81 African American and 142 Caucasian incident orolaryngeal cancer patients and 335 controls frequency-matched on age, sex, and race. In Caucasians, a significant risk increase was observed for subjects with the EH(113Tyr) variant (OR=2.1, 95% CI=1.1-4.0) and predicted high-activity EH genotypes in heavy-smokers (>or=35 pack-years; OR=3.4, 95% CI=1.2-9.6). A significant association between predicted high EH activity genotypes and orolaryngeal cancer risk was observed in Caucasian subjects with the GSTM1 null (OR=3.5, 95% CI=1.3-9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4-2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group
  • Alcohol Drinking / adverse effects
  • Epoxide Hydrolases / genetics*
  • Epoxide Hydrolases / metabolism
  • European Continental Ancestry Group
  • Female
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Laryngeal Neoplasms / genetics*
  • Logistic Models
  • Male
  • Middle Aged
  • Neoplasm Proteins / metabolism*
  • Polymerase Chain Reaction / methods
  • Risk Factors
  • Smoking / adverse effects

Substances

  • Neoplasm Proteins
  • Glutathione Transferase
  • glutathione S-transferase M1
  • Epoxide Hydrolases